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Advanced in vitro safety assessment combining reconstructed human tissues with mechanistic gene-expression endpoints for chemicals, complex ingredients, formulations and medical devices.

Human 3D Tissues. Mechanistic Toxicology. Better Safety Decisions.

Brain Cancer Chromosomes. Chromosomes prepared from a malignant glioblastoma visualized by spectral karyotyping (SKY) reveal an enormous degree of chromosomal instability -- a hallmark of cancer. Created by Thomas Ried, 2014

Team members

One technology. Multiple toxicology applications

Relevant, faithful to human biology

HUMAN 3D TISSUES

Toxicogenomics to decode biological responses

MECHANISTIC GENE SIGNATURES

Mechanism-based assays for better decisions

PREDICTIVE SAFETY ENDPOINTS

List

Published validated assays today. Expanding the platform

Skin Sensitization Hazard identification &amp; potency

SENS-IS™

Skin Irritation Genomic-based quantification

IRR-IS™

Ocular Irritation. Genomic-based quantification

EyeIRR-IS™

Skin Sensitization. Improved skin barrier and metabolic capacities

SENS-IS on FTS

Schematic representation of IS-RhE and IS-hCE

Guideline Eye or Skin irritation with MTT

PLATFORM EXPANSIONS

Photo-irritation and photo-sensitization in a single assay

Laboratory computer screen displaying detailed biomarker analysis data and molecular diagnostic results

PhotoSENS-IS

Respiratory sensitization, Using genomic signature on 3D lung tissue

Close-up of illuminated DNA double helix molecular model on laboratory surface with precision lighting

RespSENS-IS

In vitro test for Non Genotoxic Carcinogen using single cell genomic and XAI on lung tissies

Researcher examining brain tissue under digital scanning microscope, with vibrant neuronal network visualizations displayed on analytical monitor

PROG-IS

Local tolerance &amp; sensitization (under development)

Oral / Gingival

Custom Assay Development

Test the products you actually need to assess

Pure substances and reference compounds

Chemicals

Fragrances, essential oils, plant extracts, UVCBs, silicones, waxes ...

Complex mixtures

Cosmetics, Personal care, household and industrial products

Finished products

Polymers, leachables, extractables, coatings

Medical devices and extracts

Hydrophobic materials, poorly soluble substances, waxes, resins, polymers

Difficult-to-test substances

Services

Trusted science for safer products

Studies conducted within our GLP-certified test facility

GLP / BPL certified

Methods designed to support regulatory safety assessment

Regulatory focused